Antioxidant

GLUTATHIONE
-produced in the human liver



-also known as gamma-glutamylcysteineglycine & GHS

-small protein composed of three amino acids:
~cysteine

~glutamic acid

~glyceine

-found in two forms:
~monomer:
single molecule of the protein
called reduced glutathione
active form of glutathione

~dimmer:
two the single molecules joined together
called oxidized glutathione
broken down to the single molecule by an enzyme called glutathione reductase

-white powder that is soluble in water & alcohol

-absorption rates of glutathione from food sources in the human gastrointestinal tract are low

-must be generated within the cell from its precursors before it can work effectively in the body

General Use
-cancer treatment

-antioxidant & free radical scavenger

-protecting cells from oxidative stress

-maintaining the immune system

-treatment of poisoning (e.g.paracetamol/heavy metal poisons)

-treatment of idiopathic pulmonary fibrosis


-increasing the effectiveness & reducing the toxicity of cis-platinum (chemo drug used to treat breast cancer)

-treating Parkinson's disease

-lowering blood pressure in patients with diabetes

-increasing male sperm count



-treatment of liver cancer

-treatment of sickle cell anemia

-increase energy

-improve concentration

-slow aging


-protect the skin

-enhancing the immune system

Side Effect
There are no established side effects to glutathione or to the substances used to elevate glutathione levels.But the medicine may be causing these:
~symptoms which may mean you are allergic to it:
breathing problems or tightness in your throat/chest
chest pain
skin hives, rash, itchy, swollen skin
tell your doctor if you have side effects that you think are caused by this medicine

Training & certification
-classified as an orphan drug for treatment of AIDS

-given intravenously for amelioration of the side effects of cisplatin therapy
Storage
-locked up & away from children

-away from heat & direct light

-do not store medicines in the bathroom, near the kitchen sink or in other damp places

-heat/moisture may cause the medicine to break down & not work the way it should work

-throw away medicine that is out of date

Warning
Before taking glutathione tell your doctor if you are pregnant/breastfeeding. Individual with liver malfunction is not supposed to take this product.

How Long Can a Person Take Glutathione & How Long Will the Effect Last after Stop the Treatment?
It can be taken permanently. In 1996, Italian study the therapeutic effect lasted 2 to 4 months after therapy was stopped.

Collagen

-three major parts to our skin: collagen, elastin, GAGs (Glycosaminoglycans)

-type of protein

-relation to the skin

-more than 28 types of collagen that naturally occur in the body:
~collagen one: skin, tendon, vascular,ligature, organs, bone

~collagen two: cartilage

~collagen three: reticulate

~collagen four: forms bases of cell basement membrane

-most plentiful proteins present in the bodies of mammals, including humans

-more than 80% of our skin made of collagen

-it makes up about 25% of the total amount of proteins in the body

-the combination of collagen & elastin is very important in many parts of the body

-without it, the body would, quite literally, fall apart

-as people age, collagen degradation occurs, leading to wrinkles



-processing great tensile strength, collagen functions in a manner that is very different from many other types of protein

-can be found both inside and outside of cells

-collagen fibers are important in contributing to the external structure of cells & present on the inside of some cells as well

-some skincare professionals, advise people on ways to stimulate the production of collagen in skins cells

-because it is so important in the body, collagen also has many medicine uses:


~cosmetic surgery procedures

~burns surgery

~supplement created for joint mobility

~treating & managing serious burns

~used in creating man-made skin substitutes

Functions of Collagen
-supports & connects other bodily tissues such as skin, bone, tendons, muscles & cartilage

-supports the internal organs: lung, bones, tendons

-support teeth



-provides firmness, strength, flexibility & resilience

-blood vessels rely on both collagen & elastin

-fights the visible effects of aging on the skin

-tissues development

-present in the cornea and lens of the eye in crystalline form

-hydrolyzed collagen can play an important role in weight management

-as a protein, it can be advantageously used for its satiating power

-construction of artificial skin

Deficiency
-osteogenesis imperfecta (brittle bone disease)

-Ehlers-danlos syndrome



-Alport syndrome

-Ulrich myopathy

-Atopic dermatitis

Side Effects
When used cosmetically, there is a chance of allergic reactions causing prolonged redness; however, this can be virtually eliminates by simple inconspicious patch testing prior to cosmetic use.

Sources for Medical & Cosmetic Use
Most medical collagen is derived from:
~young beef cattle (bovine) from certified BSE (Bovine spongiform encephalopathy) free animals

~most manufacturers use donor animals from either "closed herds" or from countries which have never had a reported case of BSE such as Australia, Brazil, New Zealand

~porcine (pig) tissue is also widely used for producing collagen sheet for a variety of surgical purposes

~patient's own fat, hyaluronic acid or polyacrylamide gel

~eqine

~human

Gerovital H3 (GH3)

Non Placental Anti-aging Therapy
Procaine Hydrochloride

Introduction
Based on Procaine

Gerovital H3 (or GH3 on short), has been discovered by a Romanian doctor, Prof. Dr Ana Aslan at the National Geriatric Institute in Bucharest, the capital City of Romania, in early fifties.

Being the first anti-aging therapy, Aslan's GH3 reduces free radical activity preventing damage to DNA and cellular membrane. The enhanced cellular bioenergetics optimizes ATP, the body's universal energy molecule. It also normalizes brain neuro-transmitting balance to help normalize chronobiological rhythms.

How it works to protect our cells?
Professor Aslan, the procaine founder, has concluded that Gerovital H3 (or GH3) works at ‘the cellular level’ in our body. The process of cell cycle when a person grows is:

After birth – Proliferation of new cells and some cells commence to die. The body entirely undergoes differentiation of cellular organization or getting more complex.

Age of twenties – Formation of new cells and the dying of old ones is in a balance state.

Age of thirties – A person is losing more cells than they are gaining and there is a decline in overall health condition and efficiency. At this age, the entire body or brain function begins to deteriorate.

Procaine hydrochloride, being the active ingredient in GH3 consisting of two substances that found naturally in the body. So, at a glance it is not belongs to any pharmaceutical drugs which cause undesirable side effects. The two substances, namely PABA and DEAE are belonging to the group of Vitamin B complex. When combined with these two substances are infinitely more beneficial than their separate parts and this in fact gave rise to the description ‘H3’ which was coined to describe the powerful factor in the procaine molecule. When procaine molecules break down into its constituent parts (PABA and DEAE) in intestine, these ingredients are absorbed and play vitally important roles prior to final metabolism.

PABA stimulates beneficial intestinal flora to produce vitamin K and B and also essential Folic Acid, while DEAE helps generate choline and acetycholine essential for the effective functioning of the spleen, liver, brain and nerve synapses.

By working at the cellular level GH3 has been seen to have the ability to influence both body and brain in a wide variety of ways.

Also, it increases the oxygen content of the red corpuscles up to 30%. Essentially this strengthens the immune systems and resistance to infection of any type.

Patients who treated with GH3 at some period of time have been observed to respond beneficially on the following diseases/disorders/ailments:

~Arthritis

~Migraine

~Abnormal blood pressure

~Peptic ulcers

~Acne or pimples

~Parkinson’s disease

~Hodgkinson’s disease

~Multiple sclerosis

~Arteriosclerosis

~Sickle cell anemia

~Hypoglycemia

~Hypertension

~Hypotension

~Diabetes

~Herpes

~Bad circulatory system

~Heart disease

~Angina pectoris

~Osteoporosis

~Impotence

~Frigidity

~Liver spots

~Varicose veins

~Grey hair and balding

~Wrinkles and fine lines

~Asthenia

~Edema

~Emphysema

~Neuralgia

~Excessive cholesterol

~Aging ailments such as decreased sexual desire, tiredness, erectile dysfunction, depressions, and common cough and cold

Composition
Procaine Hydrochloride
0.1000g

Benzoic Acid
0.0060g

Potassium Metabisulfite
0.0050g

Disodium Phosphate
0.0005g

Packing
Injection 5 x 5ml or 10 x 5ml
Tablet 25tabs / bottle/ 1 month supply

Contraindication
Specific allergy to procaine

Adverse reactions
No adverse reactions have been recorded.

With procaine sensitive persons, the following phenomena may however appear:

~cephalea

~shaking

~bradycardia or tachycardia

~motor or psychic restlessness

~allergic reactions

Incompatibility
Gerovital H3 should not be administered simultaneously with sulphonamides (inactivation), eserine or prostigmine.

Dosage
Parentally - 1 intramuscular (I.M.) injection three times a week, over a period of 4 weeks. The treatment should be repeated after an intermission of 1 to 2 months.

1 tablet twice daily after meal for 12 days with 13 days of convalescence. The cycle is repeated every month.

ACKNOWLEDGMENT

Procaine Hydrochloride
-also called Novocain or Novocaine

-synthetic organic compound

-used in medicine as a local anesthetic

-amino ester group

-introduced in 1905 under the trade name Novocaine

-first & best-known substitute for cocaine in local anesthesia

-unlike cocaine, it is not:
~toxic

~addicting

~irritating

-first injectable man-made local anesthetic

-created by Germany chemist Alfred Einhorn (1857-1917)
~gave the chemical trade name

~from Latin:
:Novus (meaning New)
:caine (common ending for alkaloids used as anesthetics)

-introduced into madical use by surgeon Heinrich Braun (1862-1934)

-excreted by the kidneys into the urine



-allergic reactions to procaine are usually not in response to procaine itself, but to PABA (para-amino benzoid acid)

-procaine is the primary ingredient in the controversial preparation Gerovital H3 (GH3)



-administered by injection (I.M.)

Functions
-dental anesthesia / dentistry

-nerve-block (constricting blood vessels: reduces bleeding)

-spinal



-caudal anesthesia

-reduce the pain of injection of penicillin

-improves cell metabolism



-improves concentration

-improves memory

-well-being

-improves skin complexion

-improve hair condition



-blocks the generation & construction of nerve impulse by decreasing the permeability of the nerve membrane to ions: loss of nerve function occurs:
~loss of autonomic activity

~loss of pain sensation

~loss of sensory function

~loss of motor activity

-control of premature aging

Appearance
-colorless / white odourless crystals

-white crystalline powder

-soluble in water, alcohol & slightly soluble in chloroform

-the injection:
~clear

~colorless to pale yellow

~sterile solution of procaine hydrochloride

Use in Pregnancy

It is known that Procaine hydrochloride crosses the placenta. However, limited studies on pregnant women have shown that the frequencies of malformations and congenital anomalies were not increased among the children of women who had been treated with procaine during the pregnancy. Please see below for use of Procaine during labour.

Labour: Paracervical or pudendal anaesthesia may produce changes in uterine contractility and/or maternal expulsive efforts. Maternal hypotension may occur during regional anaesthesia. Administration of local anaesthetics by paracervical nerve block during labour has been associated with a high incidence of foetal acidosis and bradycardia and has occasionally resulted in perinatal death. The risk of foetal bradycardia appears to be increased with prematurity, toxaemia of pregnancy, and foetal distress. Possible inadvertent foetal intracranial injection has reportedly occurred following attempted paracervical and/or pudendal block. This results in unexplained neonatal depression at birth, associated with high serum concentration of local anaesthetic, and seizures usually occurring within 6 hours. Prompt use of supportive measures and forced urinary excretion of the local anaesthetic has reportedly been effective for managing this complication.

Use in Lactation

It is not known whether procaine hydrochloride is distributed into breast milk. Problems in humans have not been documented, but due to lack of data the use of procaine hydrochloride is not recommended in lactating patients.

Hypersensitivity Reactions

Hypersensitivity or allergic reactions due to use of procaine are rare. These reactions may be characterised by urticaria, skin rash, redness and hives.

More serious allergic reactions include pruritus (the symptom of itching, an uncomfortable sensation leading to the urge to scratch which often results in secondary infection), angioedema (an acute painless, dermal, subcutaneous or submucosal swelling of short duration involving the face, neck, lips, larynx, hands feet, genitalia, or viscera) and anaphylaxis (an exaggerated, life-threatening hypersensitivity reaction which may be a localised wheal and flare of generalised itching, hyperaemia, angioedema, and in severe cases vascular collapse, asthma and bronchitis, and shock).

It should be noted that although skin testing in patients with suspected drug sensitivity has been recommended, the usefulness of screening for sensitivity is at present controversial. Moreover, the testing itself can cause severe or anaphylactic reactions.

Other reactions

The following reactions may also occur: transient burning at the injection site, skin discolouration, tissue irritation, neurolysis, neuritis, tissue necrosis, prolonged burning pain and sloughing.